Editorial 22/2

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Elhai et al.’s [1] study evaluates the frequency of radiological cervical spine involvement in young adults with polyarticular JIA (pJIA) compared with RA patients. The authors show that about two-thirds of patients in both groups had radiographic abnormalities in the cervical spine, including anterior atlantoaxial subluxation, erosion of the odontoid process, C1 C2 arthritis and apophyseal joi...

222-227 Steinauer

Clearly, the prevention and management of unintended pregnancy are primary health services needed by the majority of women of reproductive age, as well as many comparable men. The training that family physicians receive in family planning and first-trimester abortion is critical, yet few studies have investigated these aspects of their education. The Council on Residency Education in Family Pra...

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RNA interference (RNAi) is the process of sequence-specific post-transcriptional gene silencing triggered by double-stranded RNAs1–3. In attempts to identify RNAi triggers that effectively function at lower concentrations, we found that synthetic RNA duplexes 25–30 nucleotides in length can be up to 100-fold more potent than corresponding conventional 21-mer small interfering RNAs (siRNAs). Som...

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Mol090951 222..230

b-Adrenergic receptor blockers (b-blockers) are commonly used to treat heart failure, but the biologic mechanisms governing their efficacy are still poorly understood. The complexity ofb-adrenergic signaling coupled with the influence of receptor polymorphisms makes it difficult to intuit the effect of b-blockers on cardiac physiology. While some studies indicate that b-blockers are efficacious...